姓 名 | 居瑞军 | |
职 称 | 副教授 硕士生导师 | |
学历(学位) | 研究生(理学博士) | |
部门及职务 | 新材料与化工学院 制药工程系 | |
办公电话 |
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邮 箱 | juruijun@bipt.edu.cn | |
办公地址 |
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居瑞军,男,1986年生。2010年于北京大学药学院获得药学(理学)学士学位,2012年和2015年分别获得北京大学药剂学硕士、博士学位。2015年9月至今在大发dafa888手机经典版化学工程学院工作,副教授。主讲药剂学、分子生物学等课程。
目前主要研究新型抗肿瘤药物递送系统,天然产物的提取、纯化及生物活性分析和化妆品制剂工程等领域,担当北京市医药制造企业安全生产技术规范主要起草人以及Phytomedicine、J Drug DelivSci Tec等杂志审稿人。
主要科研项目:
1.国家自然基金青年项目,81703453,肿瘤微环境响应型脂质复合物的构建及其抗乳腺癌转移的效应与机制研究,2018/01-2020/12,主持;
2.北京市教委科技类一般项目,KM201810017002,中药“扶正固本”方联合靶向脂质体抗耐药肺癌的研究,2018.01-2020.06,主持;
3.北京市优秀人才培养资助项目,2016000020124G058,抗肿瘤干细胞级联靶向性纳米胶束的构建及表征,2017/01-2018/12,主持;
4.大兴区科学技术委员会科技项目,KT201801321,新型抗自由基神经酰胺脂质复合物的构建及生物学评价技术测试,2018/01-2019/12,主持;
5.企业委托课题,外用制剂开发-生物活性成分等制备成软膏和水剂的技术开发,2018/07-2018/12,主持;
6.企业委托课题,大兴区医药制造企业危险化学品使用量调查,2018/07-2018/09,主持;
7.企业委托课题,面膜液制备成为固体形态样品研究和技术开发,2018/01-2019/01,主持;
8.企业委托课题,蟾酥萃取物有效部位筛选,2016/08-2016/11,主持。
代表性学术论著:
1.Ju RJ#, Mu LM#, Lu WL*, et al. Development of functional docetaxel nanomicelles for treatment of brain glioma. Artif Cells NanomedBiotechnol. 2018 Mar. doi. 10.1080/21691401.2018.1446971. [Epub ahead of print]
2.Ju RJ, Li XT*, et al. Octreotide-modified liposomes containing daunorubicin and dihydroartemisinin for treatment of invasive breast cancer. Artif Cells NanomedBiotechnol. 2018 Jan. doi: 10.1080/21691401.2018.1433187. [Epub ahead of print]
3.Ju RJ, Li XT*, et al. Hyaluronic acid modified daunorubicin plus honokiol cationic liposomes for the treatment of breast cancer along with the elimination vasculogenic mimicry channels. J Drug Target. 2018 Jan. doi: 10.1080/1061186X.2018.1428809. [Epub ahead of print]
4.Gu QY, Ju RJ*, Li XT*, et al. Nanostructured Layered Terbium Hydroxide Containing NASIDs: In Vitro Physicochemical and Biological Evaluations J. Nanosci. Nanotechnol. 2018; 18, 5320-5326.
5.Zeng F#, Ju RJ#, Lu WL*, et al. Efficacy in Treating Lung Metastasis of Invasive Breast Cancer with Functional Vincristine Plus Dasatinib Liposomes. Pharmacology. 2018; 101(1-2):43-53.
6.Ju RJ, Li XT*, et al. PTD modified paclitaxel anti-resistant liposomes for treatment of drug-resistant non-small cell lung cancer. J Liposome Res. 2017 May. doi: 10.1080/08982104.2017.1327542. [Epub ahead of print]
7.Ju RJ, Gu QY*. Biohybrid based on layered terbium hydroxide and applications as drug carrier and biological fluorescence probe. ApplOrganometal Chem. 2017; e3926.
8.Mu LM#, Ju RJ#, Lu WL, et al. Dual-functional drug liposomes in treatment of resistant cancers. Adv Drug Deliv Rev. 2017 Jun 1; 115:46-56.
9.Ju RJ#, Zeng F#, Lu WL*, et al. Destruction of vasculogenic mimicry channels by targeting epirubicin plus celecoxib liposomes in treatment of brain glioma. Int J Nanomedicine. 2016; 11: 1131-46.
10.Ju RJ, Lu WL*, et al. Liposomes, modified with PTD(HIV-1) peptide, containing epirubicin and celecoxib, to target vasculogenic mimicry channels in invasive breast cancer. Biomaterials. 2014; 35(26):7610-21.
11.Ju RJ, Lu WL*, et al. Targeting drug delivery systems for circumventing multidrug resistance of cancers. Therapeutic delivery. 2013; 4(6):667-71.
12.Ju RJ#, Huang RJ#, Lu WL*, et al. Separation of injectable salidroside by column chromatography of macroporous resins for treating myocardial ischemia. Science China Chemistry, 2012, 55(7): 1435-44.
13.居瑞军, 李学涛*, 等. 穿膜肽修饰紫杉醇和他莫昔芬脂质体中主药含量测定[J]. 中国民族民间医药, 2017, 26(21):13-15.
14.居瑞军, 李学涛*, 等. RGD肽修饰的异长春花碱-粉防己碱脂质体的制备及体外抑瘤作用研究[J]. 中国药房, 2017, 28(25):3549-3552.
15.居瑞军, 吕万良*, 等. 功能化表阿霉素脂质体的主药含量测定及体外释放考察[J]. 大发dafa888手机经典版学报, 2017, 25(02):6-10.
16.居瑞军,张强*,吕万良*, 等. 红景天苷注射剂的制备及其在大鼠体内药动学研究[J]. 中国药学杂志. 2012, 47(18): 1497-1502.